Alzheimer's Disease-Related Amyloidopathy in Visual Impairment

AD is a devastating neurodegenerative disease and is the primary cause of dementia. Amyloidopathy and tauopathy underlie the two pathological hallmarks in the AD brain [1-4]. Recently, many reports described that visual disturbance occurs in AD patients, which might be affected by amyloidopathy [5-7]. Interestingly, considerable studies using AD animal models demonstrate devastating amyloidopathy not only in the brain but also in the eye, supporting the role of amyloidopathy in the pathology of visual impairment. This study aims to describe the progress that has been made in understanding the pathophysiology and pathogenesis of AD, focusing on the amyloidopathy in the visual impairment. We will discuss the background of AD, the visual changes in AD patients and the involvement of amyloidopathy in several common eye disorders. And then we will discuss the findings of amyloidopathy in the eye of AD mouse models.